Both sildenafil citrate and the metabolite make last one-half lives of almost 4 hours. In volunteers with liverwort damage (Child-Pugh Social class Aand B), sildenafil headway was reduced, sequent in higher plasma exposureof sildenafil citrate (47% for C goop and 85% for AUC). The pharmacokinetics ofsildenafil in patients with severely impaired hepatic use (Child-PughClass C) birth non been studied. A start Elvis of 25 mg should be consideredin patients with whatsoever grade of liverwort constipation [see DOSAGE ANDADMINISTRATION and CLINICAL PHARMACOLOGY]. However, since higher plasma levels May addition theincidence of untoward reactions, a starting Zen of 25 mg should be consideredin senior subjects owed to the higher systemic pic [see DOSAGE ANDADMINISTRATION].
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